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Association of polymorphisms in 5-HTT (SLC6A4) and MAOA genes with measures of obesity in young adults of Portuguese origin

机译：5-HTT多态性（sLC6a4）和maOa基因与葡萄牙血统年轻人肥胖指标的关联

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Objectives: To investigate the association of polymorphisms in SLC6A4 and MAOA genes with overweight (including obesity). Material and methods: Young adults (n = 535) of Portuguese origin were genotyped for the SLC6A4 polymorphisms 5-HTTLPR and STin2 and a MAOA VNTR. BMI and body fat percentage were measured and a questionnaire was used to assess individual’s sport practicing habits. Results: In whole study sample, haplotype-based analysis revealed significant association with overweight/obesity for the individual 5-HTTLPR/Stin2 haplotype L10 (p = 0.04). In men, the MAOA 3R genotype was nominally associated with body fat (p = 0.04). In inactive individuals, overweight/obesity was found significantly associated with 5-HTTLPR L-allele (p = 0.01) and nominally associated with STin2 10-allele (p = 0.03). A significant association was also found testing for all haplotype effects (χ2 = 8.7; p = 0.03). Conclusions: We found some evidences for the association of SLC6A4 and MAOA genes with measures of obesity. Our results suggest physical inactivity accentuates the influence of SLC6A4 polymorphisms on obesity risk.
机译：目的：探讨SLC6A4和MAOA基因多态性与超重（包括肥胖）的关系。材料和方法：对葡萄牙裔的年轻人（n = 535）进行SLC6A4多态性5-HTTLPR和STin2和MAOA VNTR的基因分型。测量BMI和体脂百分比，并使用问卷调查表来评估个人的运动习惯。结果：在整个研究样本中，基于单倍型的分析显示，个体5-HTTLPR / Stin2单倍型L10与超重/肥胖显着相关（p = 0.04）。在男性中，MAOA 3R基因型名义上与体脂有关（p = 0.04）。在非活动个体中，发现超重/肥胖与5-HTTLPR L等位基因显着相关（p = 0.01），名义上与STin2 10等位基因相关（p = 0.03）。还发现所有单倍型效应均存在显着相关性（χ2= 8.7，p = 0.03）。结论：我们发现了一些证据表明SLC6A4和MAOA基因与肥胖症有关。我们的研究结果表明，缺乏运动会加剧SLC6A4多态性对肥胖风险的影响。

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